Last week, we released the 250th episode of our podcast, Knock Knock, Hi! 🎉
To celebrate, we're taking a look back through some of our favorite moments and greatest hits. It's been a wild ride, so we hope you'll join us for this ride down memory lane.
And if you haven't listened to the show yet – there's no time like the present! We can't wait to do this again in another 250 episodes.
Enjoy!
The Glaucomfleckens
What We've Learned In 250 Podcast Episodes
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Almost two years ago, we decided to embark upon an adventure never before attempted by anyone else with a social media presence that’s taken off.
Yes, it was incredibly bold and brave of us, but we knew we needed to do the unthinkable: Start a podcast.
... Ok, so we weren’t the first people to try this out. At all.
We were hardly even the first internet-famous-married-couple-where-at-least-one-spouse-is-a-doctor to do it. Hell, our Episode 62 guests Dr. Sydnee & Justin McElroy have been hosting their medical comedy show Sawbones since 2013. (You should check that one out, by the way.)
Sarcasm aside, the podcast world is incredibly saturated here in the big 25. So, what made us feel like it was worth taking the jump?
A few things, actually – and they aren’t just Will’s deep need to talk about eyeballs as much as possible.
Building Connections
​The whole point of social media is to be, well, social.
At a time where a lot of people are feeling increasingly isolated from one another, we wanted to have a space for conversation with other people in our corner of the internet, and beyond.
In fact, that necessity for connection was something we spoke about with US Surgeon General Vivek Murthy. Partnering with him to amplify this important messaging is one of our proudest moments on the show.
We’ve also been lucky enough to sit down with prominent voices on medical social media, like Dr. Mike, Dr. Danielle Jones, and Dr. Joel Bervell. We’ve also connected with incredible clinician content creators like podcasters Amie Varley and Sara Fung and Nurse Jen Hamilton.
​Hearing all of their unique perspectives has been such a pleasure for not only us, but our audience as well. But of course, talking about medicine isn’t just for practicing clinicians.
We had social worker and The Flipside Life founder Hayley Harlock on to talk about the unique challenges faced by families of medical professionals.
Another guest and Stanford Medicine’s Writer-in-Residence, Dr. Laurel Braitman, has done incredible work surrounding themes of grief, mental health, and co-survival.
The list goes on. Point is: healthcare connects us all, whether we’re clinicians, patients, or their families. Our podcast is meant to be a place for those connections to come to life.
Telling Stories
​If you’ve been following us for a while, you know we’ve got a bit of a crazy story.
The TLDR: we started dating in college. Between then and now, we went through a whole lot of school, had two kids, and dealt with Will’s two bouts of testicular cancer.
Oh, and a sudden cardiac arrest that Kristin saved him from with 10 minutes of chest compressions.
And somewhere along the way, Will started being funny online, and we turned that into a growing educational media business. So, yeah, we’ve been busy.
We’ve told those wild tales in many formats over the years, and this podcast has given us another place to keep it going.
At the same time, we’ve shared other stories that are important to our goal of making the world of healthcare a more compassionate one.
​Will has gotten real about the times when medicine has nearly broken him. Kristin has shared her experiences as a co-survivor of Will’s health crises, as well as some of her own health story in living with ARFID (Avoidant/Restrictive Food Intake Disorder).
We’ve had others share their stories, too – like OG YouTuber and comedian Lisa Schwartz, who talked with us about developing postpartum cardiomyopathy after the birth of her first child. Featuring the patient side is important, and something we’d love to do more often.
One exciting thing we've gotten to do is tell stories about what the future could look like. We've talked with Dr. Eric Topol (twice!) about the role of AI in medicine, and how we can navigate the positives and negatives of this technology to achieve the best possible outcome.
Humanizing Healthcare
​This is really the pinnacle of our mission. Medicine is fundamentally an act of compassion, love, and care.
But, there sometimes seems to be little room for the humanity of it all. For doctors, for patients, for their families – everyone.
We could probably make an entire playlist of all the times we’ve talked about the biggest issues with our healthcare system. In fact, let’s just drop some of these below:
That’s barely scratching the surface.
Our goal in speaking out about these topics is to bring light to the fact that it’s not doctors vs. patients, or doctors vs. co-survivors – it’s all of us against a broken system.
One of our proudest accomplishments in this regard has actually been an entirely different podcast.
​We teamed up with psychiatry residents Preston Roche and Margaret Duncan to help produce their show, How To Be Patient. It focuses on better understanding patients’ (and clinicians’) relationships with their conditions in a changing world, and we can’t recommend it enough to anyone in any part of the medical field.
This is all to say, these conversations have meant a lot to us. Getting to talk with so many incredible people – and sometimes, just each other – has been one of the coolest parts of this job.
We’ve had an incredible journey over these past 250 episodes of Knock Knock, Hi! Here’s to sharing many, many more conversations with all of you.
We shared this piece from Sepsis Alliance, but missed the mark in our originalphrasing. We apologize for any concern this may have caused. We'd like to issue the following correction:
The only way to prevent sepsis is to prevent infection – but even with every step taken correctly, this isn't always possible. Any infection can lead to sepsis, even if the person is otherwise healthy.
Read below to learn more about fighting back against sepsis, and how you can make an impact.
Sepsis Awareness Month: Raising Awareness to Save Lives
When Will went into cardiac arrest in the middle of the night, it was my immediate response that helped saved his life. When someone goes into sepsis, that same kind of swift action is necessary to save their life, too.
In honor of Sepsis Awareness Month, we’re teaming up with the Sepsis Alliance to share vital information about this dangerous condition. Keep reading to learn more about how you can join the fight against sepsis.
-Kristin
September is Sepsis Awareness Month.
It's a critical time to shine the spotlight on sepsis, a life-threatening emergency that happens when your body’s response to an infection damages vital organs and, often, causes death.
Why it matters:
- Sepsis is the leading cause of death in U.S. hospitals
- Sepsis affects an estimated 49 million people worldwide each year
- Sepsis takes 11 million lives around the world each year
- Sepsis is the #1 cost of hospitalization in the U.S. at an estimated $62 billion annually.
Sepsis Alliance has resources to empower the public, educate healthcare professionals, connect survivors and caregivers, and inspire innovation in the fight against sepsis. Importantly, Sepsis Awareness Month is a dedicated time to raise awareness and amplify the voices of those affected by sepsis.
In 2025, Sepsis Alliance entered a new field: podcasts! The Sepsis Spectrum, hosted by Nicole Kupchik, a critical care nurse, features real-life stories from survivors, clinicians, and caregivers, exploring a range of sepsis and AMR experiences, and offering free CE credits.
Join us this Sepsis Awareness Month to help spread the word. Together, we can save lives.
Visit sepsis.org to learn more about sepsis and subscribe to The Sepsis Spectrum on your favorite podcast platform.
In Last Month's Issue
​If you’ve listened to our podcast, you may have heard Will use the term “pants patient”.
When he says this, he means a call about a patient that would cause him, a noted internet-comedian ophthalmologist with copious work-life balance, to immediately put on his pants and head to the hospital to see a patient.
Basically, someone having a really bad time with their eyeballs.
In last month's deep dive, Will explained four kinds of cases that fit the bill, and how emergency physicians can best prepare these patients for the on-call ophthalmologist when they arrive. (Wearing pants. We promise.)
Did A Fantastic Human Share ​
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